HBV Treatment Management
in Sharp Focus

The Aptima HBV Quant assay quantifies HBV DNA and is intended for use as an aid in the clinical management of patients with chronic HBV infection.1

Quantitate With Confidence

The Aptima HBV Quant assay utilizes a unique dual-target design, providing accuracy in the face of high and low viral loads, genotype variation and mutations, so you can deliver trusted results from baseline measurement throughout treatment.

Unique design. Ultimate confidence.

The Aptima HBV Quant assay is a dual-target molecular assay for HBV treatment management.1

  • Targets 2 highly conserved regions in the polymerase and surface genes.
  • Provides added tolerance to mutations in the HBV genome.
  • Ensures accurate quantitation over a wide linear range.

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Dynamic range for a dynamic target.

With a wide linear range, the Aptima HBV Quant assay accurately quantifies HBV DNA as low as 10 IU/mL and as high as 1 billion IU/mL in plasma and serum samples, for reliable results even as viral load peaks and declines over the course of treatment.1

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The linear range of the Aptima HBV Quant assay has been thoroughly validated across HBV genotypes A-H, for added confidence in your results.1

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Track even low-level concentrations of HBV virus across all major HBV genotypes.

The Limit of Detection (LoD) of the Aptima HBV Quant assay is 4.8 IU/mL in plasma samples and 5.9 IU/mL in serum samples, from only 500 μL of reaction volume.* The range of quantitation of the assay is 10 IU/ml – 9 log10 IU/mL.

The LLoQ of the Aptima HBV Quant assay has been thoroughly and rigorously validated across HBV genotypes A-H with thousands of data points, across multiple reagent lots, instruments and operators.1

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Panther goes one step further.

With the Aptima HBV Quant assay, derive neat concentrations for pre-diluted samples on the fully automated Panther system:

  • Receive quantitative results for difficult samples, such as low-volume and high titer samples.
  • Reduce the risk of human error with automated calculation of neat value.

Ordering information

*Calculated using the WHO 3rd International Standard.


  1. Aptima HBV Quant assay. US package insert AW-15644. Hologic, Inc.; 2018.